BRCA1 / BRCA2 gene mutations and prostate cancer

The BRCA genes, and their link with prostate cancer, have been making headlines recently. For some time, we have known that there is a higher risk of aggressive prostate cancer in people with mutations of these genes.
Management of Localised Kidney Cancer

Alexander Kutikov, MD is a Surgical Oncologist and Associate Professor of Urologic Oncology at the Fox Chase Cancer Center in Philadelphia. He is a highly published author and experienced presenter on the topic of Urological Cancer, and is very active in Social Media in Urology. In this Guest Post, Alex gives a concise account of the diagnosis and treatment options for localised kidney cancer. He explains what you need to know, and what you should ask your surgeon.
What is GreenLight Laser treatment?

What is GreenLight Laser Treatment?
GreenLight laser is a treatment that combines the effectiveness of Transurethral Resection of the Prostate (TURP), with fewer side effects. GreenLight uses laser energy to remove enlarged prostate tissue. This results in an open channel for urine flow, but with less risk of sexual and other side effects common with TURP.
Prostate brachytherapy for younger men

An exciting paper from the Memorial Sloan Kettering Cancer Centre supports the use of LDR brachytherapy for prostate cancer in men aged less than 60 years.
Prostate Cancer Support in South Australia

Continuing the Guest Post series, this week David Merry talks about his role as Secretary of the South Australia and Northern Territory Chapter Council of the Prostate Cancer Foundation of Australia. David is also Chairman of the Prostate Cancer Action Group (SA) Inc. Locally, these groups provide great levels of support to men with prostate cancer and their families
Prostate Cancer World Congress in Melbourne

This week sees the Prostate Cancer World Congress meeting in Melbourne, from 7th to 9th August.
The meeting brings together experts in prostate cancer management to discuss latest developments in basic science understanding of prostate cancer, PSA testing and screening, active surveillance and prostate cancer treatment.
International experts Thomas Ahlering, William Catalona, and Patrick Walsh will join many other faculty in delivering a packed program.
Adelaide Urologists Nick Brook and Denby Steele will be attending. Follow @nickbrookMD on twitter, or following the twitter hashtag #PCWC13 for live updates of the conference.
mpMRI in the Diagnosis of Prostate Cancer

The diagnosis of prostate cancer is plagued by two issues. The first is the potential to ‘overdiagnose’ cancer, which means that small, low-grade cancers that may never cause problems are detected, and then potentially treated (also know as ‘overtreatment’). The second problem is that some more aggressive cancers may be missed with investigation. Unfortunately, these two problems are part and parcel of all tests in medicine.
The standard approach to diagnosis of prostate cancer has consisted of a PSA blood test and, if necessary, a prostate TRUS biopsy. These tests, when combined, can be effective but do lead to an element of ‘overdiagnosis’ & ‘overtreatment’ and occasionally more aggressive cancers can be missed.
Kidney cancer – a new class of drugs to watch for the future

The American Society of Clinical Oncology Annual meeting is in Chicago this week, and promising data on a new class of cancer drugs for will be presented.
Drugs known as Anti-PD-1 are a type of immune-therapy. PD-1 is a receptor on the surface of T cells, the immune system's disease fighters.
Erectile dysfunction in younger men - more common that thought

Erectile dysfunction (ED), or impotence, is a condition where a man is unable to get or maintain an erection that is sufficient for intercourse. Urologists are commonly consulted about this problem.
Active surveillance in prostate cancer – cost analysis

Australia has a high proportion of men on active surveillance after a diagnosis of prostate cancer. This is encouraging, and indicates that the country is leading the way in a balanced approach to prostate cancer.
Active surveillance is a structured approach to ‘low-risk’ or ‘very low-risk’ prostate cancer, where it is felt that there is only a small chance the cancer will ever cause problems.
Agent Orange linked to aggressive prostate cancer in Vietnam Veterans

Agent Orange was one of the herbicides and defoliants used by the U.S. military during the Vietnam War from 1961 to 1971.
A 50:50 mixture of 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid, Agent Orange was later found to be contaminated with 2,3,7,8-tetrachlorodibenzodioxin, a highly toxic dioxin.
This combination of agents has been linked to a number of serious negative health effects, which are well known.
da Vinci Robot: Prostate Surgery, Kidney Surgery, and More
Prostate Health Index (phi) blood test for Prostate Cancer

The phi – Prostate Health Index. This is a blood test now available that may help make the diagnosis of prostate cancer more accurately.
PSA and %freePSA are commonly used blood tests, which help identify men with prostate cancer. Although these tests can be useful in some men, the tests can be positive when no prostate cancer is present (or only a low risk prostate cancer is present), and the tests can be negative when an aggressive prostate cancer is present.
Active surveillance for low grade prostate cancer

Active surveillance for prostate cancer – The PRIAS project
Prostate cancer does not always need treatment. If the cancer does not look aggressive on pathological examination under the microscope, and if there is only a small amount of cancer found on biopsy, it may be sensible and safe to closely watch the cancer rather than treat it.